So I've been reading through a very interesting research study conducted by the University of Sao Paulo through Phytecs Pharm, a company that has an agreement with the Brazilian government to "develop a pharmaceutical product containing synthetic cannabidiol and prove its safety and therapeutic efficacy in the treatment of epilepsy, schizophrenia, Parkinson's disease, and anxiety disorders." The goal of the study is to view the anxiolytic(anti-anxiety) and antidepressant effects of CBD in both animal and human trials.
Lab mice were tested in elevated plus mazes also known as EPMs. The EPM test has been used for years to test the efficacy of anxiolytic medications due to the wide-open spaces and varying elevations that induce stress to the mice.
In these trials, researchers found that low doses of CBD (10mg) were very effective in their anxiolytic effect and had similar results to mice that were given anxiolytic drugs. Although, when researchers tested the mice with a large dose of CBD (100mg) there were no anxiolytic effects.
The human trials consisted of a group taking low doses of CBD, a high dose group, and a placebo group. The subjects were all healthy volunteers and were tested using the Simulated Public Speaking Test (SPST). As with the mice, subjects in the low dose CBD group has tremendous anxiolytic effects whereas the high dose group did not and has results similar to the placebo group. Multiple tests similar to this were conducted afterwards and all with the same underlying conclusion: Low doses of CBD are more beneficial than large doses for an anti-anxiety effect.
BUT WAIT THERE'S MORE!!!
Although they found that larger doses of CBD were ineffective against anxiety, they did find incredible results on large doses ability to create an antipsychotic effect similar to haloperidol, an antipsychotic medication used to treat many mental disorders including tourettes and parkinson's. On top of that, the CBD did not cause catalepsy which is a terrible side effect of many antipsychotic medications that induces seizure-like episodes. And it gets even better because after elongated usage, they showed that CBD can decrease hyperlocomotion and pre-pulse inhibition impairment caused by long-term amphetamine usage. Those results showcase CBD's ability to treat the side effects experienced by lifetime users of amphetamine pharmaceuticals.
The Official Conclusion
"In conclusion, the experimental and clinical use of CBD, a compound that does not produce the typical subjective effects of marijuana induced by Δ9-THC, has clearly shown anxiolytic, antiepileptic, and antipsychotic properties, among other effects (2). Since the 1970s, a number of scientific articles showing the potential therapeutic effects of CBD in different animal models of neuropsychiatric disorders and some clinical trials have been published. Recent investigations on the new effects of CBD and its synthetic analogs and on the comprehension of the mechanisms of action of this compounds as well as a better understanding of the endocannabinoid system have emerged. However, new questions appeared regarding the properties of CBD and its synthetic analogs that are currently under investigation, such as the safety and precise dose ranges for each disorder. Therefore, more controlled clinical trials with different and larger neuropsychiatric populations should bring important answers in the near future and support the translation of research findings to clinical settings."
I hope y'all have enjoyed my rundown of this fascinating research study! The link to the full study can be found here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161644/
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